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GLP-1 Peptides Mounjaro/Tirzepatide, Ozempic/Wegovy/Semaglutide - any experience?

48,667 Views | 119 Replies | Last: 3 days ago by DannyDuberstein
MRB10
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How long do you intend to take it?
dmart90
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I started Zepbound March 15 and I'm down 25 pounds. It's been a consistent 2-3 pounds a week. I started out at 246. I haven't been in the 220 range since 2011 when I went to Philmont with my son's Scout troop. My diet was ok before, but even when I made the effort to eat smarter it didn't seem to make a difference. I do think I'm making more healthier choices than I used to (it's easier to do when you see results); but the reality is I just don't want to eat or drink as much as I used to. My goal is to put 200 in the rearview mirror. I'll cross the bridge of a long-term strategy (this ain't it) when I'm at a proper weight.

Stuff is expensive, but it works!
91_Aggie
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MRB10 said:

How long do you intend to take it?


Thats a good question. I have the years supply and will meet my goal much faster than I thought.

Almost hoping Hims will say "We aren't allowed to refill in June...here is a $1000 refund"

I may just lower the dosage and use until I run out
-------------------------------------------------------
"91_Aggie is right again." -YankeeAg00
"91a: You are so classy." -abl
"and i find myself agreeing with 91 yet again..." -Gramercy Riffs
fc2112
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91_Aggie said:

4 month update on GLP-1. I hit One-derland today. Started at 240 on Feb 1. Hit 199.2 today. 40 pounds in 4 months with literally no effort on my part

So what is your diet and exercise like? I have been losing more like 3 lb a month, not the 10 you've been averaging and we are similar weights. I started at around 240 and was 210 this morning, but I've been taking it for about a year.

EDIT - went back and saw your earlier post.

My issue is me not keeping my diet under control. And by diet, I mean craft beer consumption.
91_Aggie
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fc2112 said:

91_Aggie said:

4 month update on GLP-1. I hit One-derland today. Started at 240 on Feb 1. Hit 199.2 today. 40 pounds in 4 months with literally no effort on my part

So what is your diet and exercise like? I have been losing more like 3 lb a month, not the 10 you've been averaging and we are similar weights. I started at around 240 and was 210 this morning, but I've been taking it for about a year.

EDIT - went back and saw your earlier post.

My issue is me not keeping my diet under control. And by diet, I mean craft beer consumption.


Yeah no real extra exercise since I started... but I did cut out alcohol entirely to speed things along. And diet really didnt change that much other than being aware that I need to make sure the calories I did take had good protein and nutrients...

And of course it helped with portion control. I'd get full so fast... and it eliminated my snack cravings.

willas
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91_Aggie said:

4 month update on GLP-1. I hit One-derland today. Started at 240 on Feb 1. Hit 199.2 today. 40 pounds in 4 months with literally no effort on my part.
Wow, congrats on hitting One-derlandthat's a huge milestone! Your experience mirrors a lot of what I've seen too. I've been on Mounjaro for a little over three months and I'm down 28 lbs. The appetite suppression and portion control have been total game changers. Same hereno intense workouts or crash diets, just more mindful eating and letting the med do its job.

The biggest challenge for me was access. My insurance wouldn't cover it at first, so I had to find a reputable way to get Mounjaro online through a licensed pharmacy abroad. It ended up being way smoother than I expected, but yeah, the cost is still a major barrier for so many people.
dmart90
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Just hit the six month mark on Zepbound. Down 41 pounds. 205 this morning. Last time I was in this weight range was around '05.

It was a pretty consistent 2-2.5 pounds a week at first, but has slowed down. Really only eat two meals a day now. Still drink too much - which I'm sure doesn't help. But I feel and sleep so much better.

Have a lot of work to do to get in shape, but this has been incredible for me.
dmart90
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Weighed is this weekend below 190. I've dropped close to 60 pounds on Zep. Never had to go above the 5 mg dosage. The weight loss has slowed, but I've been working out a little more so I hope gaining muscle has something to do with that. I've had to buy a whole new wardrobe. My energy levels are greatly improved. Sleeping better at night.

These results have me super motivated to maintain this size and weight. I haven't felt this good in years.
dmart90
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Last check-in as a Zepbound user (fingers crossed).

I've settled in around 185. It's been 30 years since I was in this weight range.

For the last 3 months I've been back on the 2.5mg introductory dose. I dropped a few more pounds and stabilized out over the last 6 weeks. Saw my doctor this morning. He's happy with where I am and says I'm ready to stop the Zepbound. He suspects my body has fully adjusted to eating less. I have a few more doses and said I can take them or not - my choice.

Took my first shot on 3/15/25. I weighed in at 247. Today? 185.5. I went from XXL shirts to L. From 42-44" waist pants to 34" (maybe going to 32s...).

I will keep weighing in on a weekly basis. And I plan to keep hitting the gym. I actually see results now! I'm sleeping better. I'm eating less. And I feel good. I'm motivated to maintain where I am.

This has been a game changer for me.
Dad
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I was at my annual check up and telling my doctor that I have had success eating low carb before but I can't make it the first three weeks without sugar so I keep failing. She suggested tirzepatide for a short period to break the sugar addiction. I got on it for 6 weeks and had no sugar or bad carbs the whole time. It was effortless. She started me on 2.5 but they reduced the dose after a few weeks and by my last shot it was 1.0 mg.

I have been off of it for over a month and continue losing weight. My doctor told me if I end up struggling again I can always get back on it.

If you are struggling with sugar/carb addiction and want to use this to break it, it is amazing. I highly recommend it. I think even longer term use is good as long as you are actually changing your lifestyle by eating whole foods, lifting weights, and getting your steps in.

The reason I stopped is because I was trying to hit a protein goal every day and it felt impossible on the shot. I think it would have worked if ate four smaller protein based meals per day but I don't have time for that on work days. I was also concerned that some days my calorie intake would be super low from lack of hunger and feeling full for a long time after meals. I didn't want to destroy my metabolism by chronic low calorie days.

If I end up hitting a hard plateau and can't get past it with all the tools I have to help with weight loss then I will get back on a micro-dose again and try eating smaller meals throughout the day to get enough protein.
wcb
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Dad said:

I was at my annual check up and telling my doctor that I have had success eating low carb before but I can't make it the first three weeks without sugar so I keep failing. She suggested tirzepatide for a short period to break the sugar addiction. I got on it for 6 weeks and had no sugar or bad carbs the whole time. It was effortless. She started me on 2.5 but they reduced the dose after a few weeks and by my last shot it was 1.0 mg.

I have been off of it for over a month and continue losing weight. My doctor told me if I end up struggling again I can always get back on it.

If you are struggling with sugar/carb addiction and want to use this to break it, it is amazing. I highly recommend it. I think even longer term use is good as long as you are actually changing your lifestyle by eating whole foods, lifting weights, and getting your steps in.

The reason I stopped is because I was trying to hit a protein goal every day and it felt impossible on the shot. I think it would have worked if ate four smaller protein based meals per day but I don't have time for that on work days. I was also concerned that some days my calorie intake would be super low from lack of hunger and feeling full for a long time after meals. I didn't want to destroy my metabolism by chronic low calorie days.

If I end up hitting a hard plateau and can't get past it with all the tools I have to help with weight loss then I will get back on a micro-dose again and try eating smaller meals throughout the day to get enough protein.

Guessing you lost some weight those six weeks?
Dad
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wcb said:

Dad said:

I was at my annual check up and telling my doctor that I have had success eating low carb before but I can't make it the first three weeks without sugar so I keep failing. She suggested tirzepatide for a short period to break the sugar addiction. I got on it for 6 weeks and had no sugar or bad carbs the whole time. It was effortless. She started me on 2.5 but they reduced the dose after a few weeks and by my last shot it was 1.0 mg.

I have been off of it for over a month and continue losing weight. My doctor told me if I end up struggling again I can always get back on it.

If you are struggling with sugar/carb addiction and want to use this to break it, it is amazing. I highly recommend it. I think even longer term use is good as long as you are actually changing your lifestyle by eating whole foods, lifting weights, and getting your steps in.

The reason I stopped is because I was trying to hit a protein goal every day and it felt impossible on the shot. I think it would have worked if ate four smaller protein based meals per day but I don't have time for that on work days. I was also concerned that some days my calorie intake would be super low from lack of hunger and feeling full for a long time after meals. I didn't want to destroy my metabolism by chronic low calorie days.

If I end up hitting a hard plateau and can't get past it with all the tools I have to help with weight loss then I will get back on a micro-dose again and try eating smaller meals throughout the day to get enough protein.

Guessing you lost some weight those six weeks?


It definitely comes off a lot faster on the shot than without the shot. I am just following advice to keep a smaller calorie deficit, lift weights, hit a protein goal, walk a lot. With the shot some days I would only eat 1100 calories due to lack of hunger. I was probably averaging 1400 to 1500 calories per day. I am currently losing more than a pound per week eating 2100 calories per day. I feel better doing it slow like this and I am getting stronger every week. When I was on the higher dose of the shot I had some days where I felt low on energy and was freezing in a room that no one else thought was cold.
AgEng06
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Reel Aggies said:

On 2mg ozempic qweek, down 47# from 336 to 289. Appetite has really dropped off. I have lost muscle but a lot of water (bloat) and fat. On TRT so has preserved some muscle I think. I feel great. Joints don't ache anymore, BP great on half the BP meds and my A1c is back around 5.6-5.7. I have zero plans to get off. My insurance bc/bs covers it, $15/mo. The improvements in my health and long term CV benefits outweigh any potential risks.

Retatrutide is going to be the new one to watch. It shows to actually reverse fatty liver.

This guy nailed it way back on page 1...
True Anomaly
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Dad said:

I was at my annual check up and telling my doctor that I have had success eating low carb before but I can't make it the first three weeks without sugar so I keep failing. She suggested tirzepatide for a short period to break the sugar addiction. I got on it for 6 weeks and had no sugar or bad carbs the whole time. It was effortless. She started me on 2.5 but they reduced the dose after a few weeks and by my last shot it was 1.0 mg.

I have been off of it for over a month and continue losing weight. My doctor told me if I end up struggling again I can always get back on it.

If you are struggling with sugar/carb addiction and want to use this to break it, it is amazing. I highly recommend it. I think even longer term use is good as long as you are actually changing your lifestyle by eating whole foods, lifting weights, and getting your steps in.

The reason I stopped is because I was trying to hit a protein goal every day and it felt impossible on the shot. I think it would have worked if ate four smaller protein based meals per day but I don't have time for that on work days. I was also concerned that some days my calorie intake would be super low from lack of hunger and feeling full for a long time after meals. I didn't want to destroy my metabolism by chronic low calorie days.

If I end up hitting a hard plateau and can't get past it with all the tools I have to help with weight loss then I will get back on a micro-dose again and try eating smaller meals throughout the day to get enough protein.

You could also just try doing high-carb instead. Carbs are not the devil that others have portrayed them to be. Especially high-fiber complex carbs.

In fact, if you moved to a higher protein/higher fiber approach, you might find that it's easier to sustain a calorie deficit. Keep the protein on the leaner side more often- but notice I didn't say avoid high-fat protein totally

DannyDuberstein
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https://www.wsj.com/health/wellness/glp-1-weight-loss-drugs-stop-what-happens-162b6dd2?st=o4uQdn&reflink=article_imessage_share

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