No longer travel for work, but when I did I bought a B&R that had a garment compartment. It was perfect for work travel. I'd take my work clothes (slacks, dress shirts, occasional suit jacket) w/ the hangers, straight into the garment section, then when I got to the hotel right into the closet. Still had the standard carry on section for shoes, toiletries bag, etc.
I've had it for about 13 years and still holding up great, granted I stopped traveling weekly about 8 years ago. I do still use it for all my personal travel, though.